Evaluation of anti-inflammatory effect of Calotropis gigantea and Tridax procumbens on Wistar albino rats

Calotropis gigantea Linn and Tridax procumbens Linn, are well documented medicinal plants distributed in Asia and Africa and are useful for many ailments. The anti-inflammatory activity of low dose of the aqueous extract of T. procumbens and ethanolic extract of C.gigantea were assessed on carrageenan induced paw edema and compared with standard drug Ibuprofen. The oral administration of 400mg/kg of C.gigantea and 300 mg/kg of T. procumbens were showed significant antiinflammatory activity more than that of 100mg/kg of Ibuprofen. This study also proved the greater anti-inflammatory action due to the combined effect of C. gigantea and T. procumbens with Ibuprofen than Ibuprofen alone. This may be due to the potentiation of its inhibitory effect on the synthesis and release of various inflammatory mediators.